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    Water vapor ablation yields positive results at 2 years

    BPH patients show improved IPSS, BPH impact index scores vs. medical monotherapy

    Boston—Treatment of lower urinary tract symptoms/BPH with convective water vapor ablation (Rezum System) appears to provide significant improvement on two key outcome measures versus medical therapy at up to 2 years, according to a study presented at the AUA annual meeting in Boston.

    The study compared water vapor ablation therapy with medical therapy based on a historical cohort from the Medical Therapy of Prostatic Symptoms (MTOPS) trial. Findings were presented by first author Nikhil K. Gupta, MD, who was with Southern Illinois University School of Medicine in Springfield at the time of the study.

    Nikhil K. Gupta, MDDr. GuptaMinimally invasive surgical therapies have aimed to “thread the needle” between surgical and pharmacologic options, said Dr. Gupta, who is currently assistant professor of urology at Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.

    “The daily grind of taking pills is an underappreciated barrier to treatment, especially for the average BPH patient who is older and likely has comorbidities requiring treatment. Symptom relief without increasing medication burden or affecting sexual function can significantly improve quality of life for our patients and can have a real impact on BPH treatment patterns moving forward,” Dr. Gupta told Urology Times.

    More on BPH: 5-ARI may have adverse metabolic effects

    Rezum uses convection energy in the form of water vapor, which distributes itself evenly within the treated tissue while remaining within collagen barriers and causing a uniform cell necrosis. According to previously published data, the treatment delivers durable symptom relief with minimal sexual side effects.

    When looking at the effect of medical therapies for BPH, the MTOPS study is considered the gold standard, he said. In three treatment arms of the trial, patients received an alpha-blocker, a 5-alpha-reductase inhibitor, or a combination of both. As there is no reliable contemporary cohort, Dr. Gupta pointed out that the high-quality MTOPS trial provides a “reliable, historical medical therapy cohort” for comparing outcomes of BPH treatments.

    In the current study, results of the Rezum II trial (J Urol 2017; 197:1507–16) were compared with the three treatment arms of the MTOPS trial. For uniformity, Dr. Gupta and colleagues limited their focus to patients with prostate volume of at least 30 mL and International Prostate Symptom Score (IPSS) of at least 13.

    Standard clinical outcomes measures were used in this study, and comparisons were performed at 3 months, 6 months, 1 year, and 2 years. In addition, propensity score weighting was used to eliminate differences in IPSS, quality of life, and prostate volume between the groups at baseline.

    Next: Better IPSS improvement at 2 years

    Aine Cryts
    Aine Cryts is a freelancer based in Boston. She is a frequent contributor to Managed Healthcare Executive on topics such as diabetes, ...

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