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    Uro Pipeline: Supplemental application submitted for advanced RCC treatment


    Study supports technology’s use in characterizing UTUC lesions

    A study published online in European Urology Focus (June 4, 2017) supports the use of Cellvizio, a confocal laser endomicroscopy platform, for the real-time histologic characterization of upper tract urothelial carcinoma (UTUC) lesions, Mauna Kea Technologies reported. In the study, 14 patients underwent flexible ureteroscopy with Cellvizio used to target biopsies, which were then read for conclusive histopathologic results. The pre-biopsy observations using Cellvizio were compared to the surgery-blinded histopathologic results and the results demonstrated a high degree of agreement between the methods. Researchers concluded that Cellvizio could be used in real-time characterization of UTUC lesions for endourologic management, follow-up of UTUC patients who had been managed conservatively, and characterization of potential carcinoma in situ lesions. Cook Medical is the exclusive partner for Cellvizio in the field of urology.

    Antibody to treat prostate, bladder Ca moves to next trial stage

    Minomic International Ltd is moving to the second stage of its MILGa clinical trial of Miltuximab, a chimeric version of MIL-38 anti-Glypican 1 antibody conjugated to the radioactive isotope 67Gallium. The study will evaluate the safety and tumor targeting of the drug in patients with prostate, bladder, and pancreatic cancer. Its primary endpoint is safety and tolerability of the drug with secondary endpoints of tumor targeting, pharmacokinetics, and dosimetry to determine relative accumulation of MILGa in various organs. The first half of the study dosed four patients with prostate cancer and two patients with pancreatic cancer. After the independent Drug Safety Monitoring Committee formally approved the continuation of the clinical trial, the remaining six patients will be dosed with the drug. Preclinical studies demonstrated that MILGa accurately targets prostate, pancreatic, and bladder cancer cells and is well tolerated and highly specific in mouse models of prostate cancer, Minomic said. 

    Ben Schwartz
    Ben Schwartz is Associate Editor, Contemporary OB/GYN.


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