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    Urethral lift: 5-year data point to procedure’s durability

    BPH treatment yields improvements in IPSS scores, Qmax

     

    Compared with baseline, mean IPSS and mean IPSS quality of life scores in the PUL arm improved by 44% and 42%, respectively, at 1 month (p<.001 for both) and by 36% and 50%, respectively, at 5 years (p<.001). Qmax was improved by 3.5 mL/s at 5 years (+44% vs. baseline).

    Further underscoring the durability of improvement provided by PUL were data on the surgical retreatment rate, which was only 13.6% (2% to 3% per year) in the PUL group.

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    “Looking at the data in other ways, 86% of men did not require another procedure for BPH, and the retreatment rate also compares very favorably with other procedures for BPH,” said Dr. Roehrborn. “For thermally based procedures, the 5-year retreatment rate ranges from 20% to 50%, and the annual retreatment rate for TURP is 1% to 2%.”

    Most done under local anesthesia

    Dr. Roehrborn also highlighted the minimally invasive nature of the PUL procedure. In LIFT, 99% of the PUL procedures were done under local anesthesia, 68% of men avoided postprocedural catheterization, and men returned to normal activities at an average of 8.6 days. In a follow-on study of men crossed over from the sham arm to PUL, all procedures were done under local anesthesia, 80% of men avoided catheterization, and the average time to return to normal activities was 5.1 days.

    “PUL is truly a minimally invasive procedure that can be offered in the office setting, and those features also make it a unique and important treatment option,” Dr. Roehrborn said.

    Dr. Roehrborn is an investigator for NeoTract, NxThera, and Procept.

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