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    Peri-op transfusion raises short-term morbidity risk

    Urologists must be 'conscientious' about performing transfusions

    Perioperative blood transfusion for patients undergoing radical prostatectomy is associated with increased short-term morbidity, according to a recent study presented at the AUA annual meeting in San Diego. 

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    “Blood transfusion in the perioperative period, either immediately after surgery or during surgery, has been associated with worse overall survival for several malignancies, including prostate cancer. It has been suggested that the allogeneic blood stimulates an inflammatory response that may promote tumor growth. Keeping this in mind, we hypothesized that the use of perioperative blood transfusion during radical prostatectomy may be associated with increased short-term morbidity,” explained first author Justin T. Matulay, MD, of Columbia University Medical Center, New York.  

    Dr. Matulay presented findings from a retrospective analysis of 30-day postoperative outcomes in men undergoing radical prostatectomy from 2005 to 2013 using the National Surgical Quality Improvement (NSQIP) database. The primary outcome was 30-day postoperative morbidity, and secondary outcomes were 30-day mortality, readmission, length of stay, infectious complications, and pulmonary complications.

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    The authors found that of the 21,293 radical prostatectomies performed during the period covered, 810 patients (3.9%) received a perioperative blood transfusion. Perioperative blood transfusion was associated with increased 30-day morbidity, readmission, pulmonary complications, and surgical site infections, they reported.

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    Benjamin P. Saylor
    Saylor is content managing editor for Urology Times.

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