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    Testosterone use triples in younger men

    Improvement seen in number of men tested prior to starting therapy

    New Orleans—Use of testosterone replacement therapy more than tripled between 2003 and 2012 in a population of reproductive-age men, according to a study presented at the AUA annual meeting in New Orleans.  

    Pravin Rao, MDDr. Rao“Over the 10 years included in our study, there was a 3.5-fold increase in testosterone use among 18- to 45-year-old men. Notably, around 2009, we saw a sharp increase in the proportion of these men who were using injection formulations over other formulations,” said lead author Pravin Rao, MD, assistant professor of urology and director of reproductive medicine and surgery at Johns Hopkins Brady Urological Institute in Baltimore.

    Read: Oral TRT agent may improve patient compliance

    Given concerns about potential misuse of these medications and consequent impacts on fertility in younger men, the FDA recommends that the use of TRT should be limited to men with medical conditions causing low serum testosterone levels. However, according to Dr. Rao, there have been few studies examining the lab testing and use of TRT in reproductive-age men in the United States.

    “We see a lot of young guys who might have been put on testosterone coming into our clinic, and they’re having unexpected azoospermia or infertility, so we had some concern. We were curious about how these numbers looked in the younger population and wanted to examine the trends and practice patterns as well as the use of testosterone in a younger population,” Dr. Rao said.

    Data were derived from outpatient pharmaceutical and service claims data using the 2003-2012 Truven Health MarketScan Commercial Claims Databases.

    Results showed that the rate of testosterone use more than tripled among 18- to 45-year-old men (from 29.2 per 10,000 in 2003 to 105.5 per 10,000 in 2012).

    NEXT: Injection use doubled after 2009

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