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    Study: mpMRI predicts lymph node involvement

    High-risk characteristics include pre-op PSA, seminal vesicle invasion

    Bethesda, MD—A combination of findings on preoperative multi-parametric magnetic resonance imaging (mpMRI) showed good accuracy for predicting lymph node involvement on final pathology in men who underwent robot-assisted radical prostatectomy (RARP) for prostate cancer, reported researchers from the National Institutes of Health, Bethesda, MD.  

    Recommended: Number of pre-op prostate biopsies not linked to outcomes

    “Preoperative evaluation of lymph node status is an essential component of staging prior to definitive therapy for prostate cancer,” said Steven Abboud, NIH Medical Research Scholar.

    “Our study suggests that for men who are part of a fusion biopsy protocol and undergoing mpMRI, the finding of high-risk features on that imaging may help urologists assess the risk of nodal involvement and decide whether or not to perform extended lymph node dissection during radical prostatectomy,” added Abboud, who worked on the study with Peter Pinto, MD, and co-authors. The findings were presented at the 2015 AUA annual meeting in New Orleans.

    mpMRI characteristics associated with having positive lymph nodes were investigated in a retrospective study that reviewed clinical information, mpMRI, and surgical pathology reports for 367 patients who underwent RARP with lymph node dissection between 2007 and 2014. Nineteen men (5%) had positive lymph nodes on postoperative surgical pathology.

    Next: Factors linked with LN invasion identified

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