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    Study: Consumer ads prompt men to seek TRT

    Researchers report increased T testing, initiation of treatment

    Findings of an ecologic study indicate that direct-to-consumer (DTC) advertising for testosterone therapy influenced men to seek treatment and was accompanied by increased testosterone prescribing, including initiation in men without clear indications for use.

    The study, which was published in JAMA (2017; 317:1159-66), analyzed associations between exposure to testosterone-related advertising in the 75 largest designated market areas representing metropolitan regions throughout the United States during the years 2009 to 2013 and new serum testosterone testing, initiation of any testosterone treatment, initiation of treatment by brand, and initiation in the absence of recent serum testosterone testing.

    The results showed increases in non-branded, condition-awareness (low testosterone) and brand-specific DTC advertising during the study period that were associated with increases in all outcome measures.

    Read - TRT and heart health: Conflicting findings published

    “There continues to be ongoing debate about the appropriateness of direct-to-consumer advertising for prescription pharmaceuticals in the United States. The findings of our study suggest that advertising may be associated with increased use of medications and potentially inappropriate use,” said lead author J. Bradley Layton, PhD, research assistant professor of epidemiology at the University of North Carolina at Chapel Hill.

    “While specific patient requests can influence treatment and prescribing behavior, the necessity, appropriateness, and risk/benefit tradeoff of testosterone treatment need to be carefully considered before initiating treatment.

    “The recent publication of several clinical trials exploring testosterone’s effects on individual symptoms should be very helpful in addressing whether testosterone treatment will yield the benefits many men are looking for,” Dr. Layton added.

    Based on review of commercial insurance claims, the study identified just over one million men in the 75 designated market areas aged ≥18 years who had a new serum testosterone test and 283,317 who initiated testosterone treatment, of whom 83,554 had treatment initiation without recent serum testosterone testing. Testosterone gels (59%) and in-office injections (36%) accounted for most of the treatment initiations.

    Next: Ad exposures lead to increased testing

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