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    Stone patients are poorly adherent with medical prophylaxis

    Only 50% of 22,000-patient cohort adherent to regimen, data indicate

     

    “Reasons to explain the very low adherence to citrate include the dosing frequency of a citrate supplementation regimen, its side effects, and cost. These findings highlight a potential barrier faced by providers who care for patients with hypocitraturia and low urine pH,” Dr. Hollingsworth said.

    The investigators noted their study has limitations. Its use of a convenience sample limits the ability to generalize the results. In addition, there is the potential for misclassification bias since it cannot be excluded that the investigated medications were prescribed for some other indication.

    Importantly, while the study identified a problem with adherence, it did not investigate its consequences on clinical outcomes.

    “Now we are actively investigating the impact that non-adherence has on outcome measures, including hospital admissions, emergency department visits, and stone-directed surgery among others,” Dr. Hollingsworth said.

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