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    RT/hormone combo cuts PCa mortality in older men

    The addition of radiation treatment to hormone therapy reduces mortality in older men with locally advanced prostate cancer compared with hormone therapy alone, according to a recently published study in the Journal of Clinical Oncology (Jan. 5, 2015).

    RELATED: Primary androgen therapy linked to reduced survival

    The authors found that hormone therapy plus radiation reduced cancer deaths by nearly 50% in men aged 76 to 85 years compared to men who only received hormone therapy.

    “Failure to use effective treatments for older patients with cancer is a health care quality concern in the United States. Radiation plus hormone therapy is such a treatment for men with aggressive prostate cancers. Patients and their physicians should carefully discuss curative treatment options for prostate cancer and reduce the use of hormone therapy alone,” said lead author Justin E. Bekelman, MD, of the University of Pennsylvania’s Perelman School of Medicine and Abramson Cancer Center, Philadelphia.

    Two landmark clinical trials have shown that radiation plus hormone therapy yields significant improvement in survival in younger men relative to hormone therapy alone (Lancet 2009; 373:301-8 and Lancet 2011; 378:2104-11). However, there has been no comparable research on treatment in older men with advanced prostate cancer until now.

    For the study, the authors examined radiation treatment and hormone therapy in the Surveillance, Epidemiology, and End Results Medicare database to compare the combination of radiation plus hormone therapy versus hormone therapy alone among 31,541 men with prostate cancer ranging in age from 65 to 85 years.

    Next: 57% mortality drop in men 65-75 years

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    Benjamin P. Saylor
    Saylor is content managing editor for Urology Times.


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