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    Number of pre-op prostate biopsies not linked to outcomes

    Urinary, erectile function found similar in men with 1 vs. 2 or ≥3 biopsies

    New York—Number of preoperative biopsies does not appear to have any clinically significant effect on self-reported urinary or erectile function outcomes at 1 year after radical prostatectomy (RP), researchers say. 

    Also see: Are you seeing a decline in PSA screening?

    Their study, which was presented at the 2015 AUA annual meeting in New Orleans and published online in BJU International (June 26, 2015), included men who underwent open or minimally invasive RP for prostate cancer at Memorial Sloan Kettering Cancer Center, New York between 2008 and 2011 and who were potent and continent preoperatively. It identified 2,082 patients, of whom 1,668 (80%) had one biopsy prior to RP, 324 (16%) had two biopsies, and 90 (4%) had three or more biopsies.

    As assessed by responses to a web-based survey, about one-third of 1,249 men with data on erectile function achieved satisfactory recovery at 12 months postoperatively, defined as an International Index of Erectile Function score ≥22. Among 1,813 men with data on urinary function, about two-thirds achieved satisfactory recovery at both 6 and 12 months, defined as a urinary domain score ≥17.

    Christopher B. Anderson, MDDr. AndersonMultivariable logistic regression analyses found that when compared to men who had a single biopsy, men who had two biopsies or three or more biopsies were equally likely to have satisfactory erectile function at 12 months and satisfactory urinary function at both 6 and 12 months, reported first author Christopher B. Anderson, MD, who conducted the study as a urologic oncology fellow at Memorial Sloan Kettering.

    “Men whose prostate cancer progresses while on active surveillance will have undergone multiple prostate biopsies prior to radical prostatectomy. The findings of our study, however, did not confirm our hypothesis that more preoperative biopsies would be associated with worse postoperative urinary and erectile function,” Dr. Anderson said.

    “Currently, therefore, we can tell patients we don’t have a reason to be concerned that undergoing follow-up biopsies during active surveillance will affect their functional outcomes if they do require radical prostatectomy.”

    Next: Most study patients not on surveillance

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