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    A new standard of care in muscle-invasive bladder Ca?

    With a median follow-up of almost a decade, patients with muscle-invasive bladder cancer who had chemoradiotherapy had improved locoregional control and a reduced salvage cystectomy rate compared to those who had radiotherapy alone, according to research presented at the Genitourinary Cancers Symposium, Orlando, FL.

    Chemoradiotherapy, with fluorouracil (5FU) and mitomycin, should be a standard of care for these patients, the study authors say.

    Also see: A new standard of care in muscle-invasive bladder Ca?

    The take-home message to urologists from the Cancer Research UK-funded phase III trial, according to co-lead author Professor Emma Hall, PhD, of the Institute of Cancer Research, London, is that chemoradiotherapy is an effective alternative to cystectomy in the primary management of muscle-invasive bladder cancer.

    “Patients preserve their bladder and have good long-term quality of life outcomes,” she said.

    Dr. Hall and colleagues studied 458 patients with muscle-invasive bladder cancer who received radiotherapy or chemoradiotherapy, and, for the radiotherapy comparison, standard radiotherapy versus reduced high-dose volume radiotherapy.

    Next: 2-year salvage cystectomy rate 11% in the chemoradiotherapy group, compared to 17% among those on radiotherapy only

    Lisette Hilton
    Lisette Hilton, president of Words Come Alive, has written about health care, the science and business of medicine, fitness and wellness ...

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