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    Multivitamin use may reduce prostate Ca recurrence


    Relative to never use, the hazard ratio (HR) for prostate cancer recurrence was 0.82 for past multivitamin use and 0.69 for current use (p-trend 0.09). When analyzed by the duration of current multivitamin use, the HRs for recurrence were 0.94 for use <5 years, 1.04 for use from 5 to 9 years, and 0.44 for use of 10 years or longer (p-trend 0.006).

    Read: Newer agent efficacious in non-metastatic castration-resistant PCa

    When the risk of recurrence was examined according to post-diagnostic multivitamin use and whether or not the patient underwent RP as primary treatment, the HR was 0.56 for current multivitamin users who underwent RP (n=845) compared with past or never users. Current multivitamin users who had not undergone RP (n=441) had a HR for recurrence of 1.24 relative to past or never users. The interaction between multivitamin use, primary treatment, and recurrence was significant at p-interaction: 0.02. No other clinical, lifestyle, or sociodemographic variables modified the association between multivitamins and risk of prostate cancer recurrence.

    “It’s likely that most long-term users of multivitamins were taking the supplements before they were diagnosed with prostate cancer,” said Dr. Van Blarigan. “More research is needed to determine whether multivitamin use lowers the risk of being diagnosed with a more aggressive type of prostate cancer or influences cancer progression after diagnosis.”

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