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    Antihistamines may play role in treating chronic prostatitis/chronic pelvic pain syndrome

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      I have been working with patients with the Chronic Fatigue Syndrome for over 20 years. The symptoms in some patients are consistent with a Mast Cell Activation Syndrome or Disease. In addition to IC and now "idiopathic" chronic prostatitis, We find a multiplicity of disorders: Irritable Bowel Syndrome, skin rashes, pruritus, fatigue, Postural Orthostatic Tachycardia Syndrome (POTS),Post Exertional Malaise(PEM),Headaches, cognitive and mood disorders. There has been "improvement" with H1-H2 and a leukotriene blocker (Singular)-Hydrocortisone has been found to stabilize the Mast Cell Membrane. HS Benadryl (for men starting with 25mg) then moving to 50 mg has been of some help as it has for women In addition to the clinical picture, an increase in serum and urine Tryptase, urinary histamines and if available a biopsy showing an increase in mast cells.Clearly much work needs to be done- but I see a plausible explanation for some issues of "idiopathic" or of unknown etiology.