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    Metastatic RCC: High-dose IL-2 ups overall survival

    High-dose interleukin-2 shows overall survival benefits in metastatic renal cell carcinoma that extend beyond complete and partial responders, researchers reported at the American Society of Clinical Oncology annual meeting in Chicago.

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    The retrospective analysis of the PROCLAIM patient registry found improved survival for those with stable and progressive disease after high-dose aldesleukin (Proleukin) in the tyrosine kinase inhibitor (TKI) era.

    The analysis also found a trend favoring patients receiving first-line versus second-line high-dose IL-2 immunotherapy, suggesting that patient selection and drug sequencing may yield better outcomes, according to a press release from Prometheus Laboratories.

    Mayer Fishman, MD, PhD, of Moffitt Cancer Center in Tampa, FL, is familiar with the registry. Moffitt is among the 35 participating sites in the registry, which includes RCC and melanoma patients.

    The main message for urologists is that although a relatively small fraction of patients gets HD IL-2, the fraction of those patients who have relatively good survival is not limited only to those with major objective response.

    “This type of study, which is nonrandomized and observational, cannot establish whether it is the patient selection or the specific treatment which results in this observation of relatively good survival,” said Dr. Fishman, who was not a study author. “However, among the patients treated with interleukin-2, the survival that is observed appears significantly better than the general kidney cancer treatment population, and this is not only seen in those with complete responses, but also among the partial response and stable disease subsets.”

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    Lisette Hilton
    Lisette Hilton is president of Words Come Alive, based in Boca Raton, Florida.

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