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    Medical expulsive therapy ineffective for ureteral stones


    The authors found no evidence that the drugs reduced pain, hastened time to stone passage, or improved health status. About 80% of patients in each group did not require additional interventions to assist with stone passage. Serious adverse events were reported in three participants in the nifedipine group and one in the placebo group.

    Read: Ureteroscopy increasingly used for pediatric stones

    Commenting about the study in the NEJM Journal Watch, family physician Bruce Soloway, MD, wrote: “This trial, designed to reflect current recommendations and clinical practice, not only definitively demonstrates the ineffectiveness of medical expulsive therapy for ureteral stones but also reaffirms the essential importance of large, well-designed, randomized trials for assessing clinical interventions and formulating treatment guidelines.”

    Also see - Study: URS found superior to SWL in stones <1.5 cm

    Separately, in commentary also published online in The Lancet (May 18, 2015), Jean de la Rosette, MD, and M. Pilar Laguna, MD, PhD, of AMC University Hospital, Amsterdam, the Netherlands, wrote: “This study… removes, beyond any reasonable doubt, any positive expectations with respect to α blockers in the treatment of ureter stones.”

    Next: Twitter reacts to paper

    Lisette Hilton
    Lisette Hilton, president of Words Come Alive, has written about health care, the science and business of medicine, fitness and wellness ...


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