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    Lipid metabolism linked to pediatric stone formation


    The study is the first to show a marked increase in urinary excretion of lipid metabolism and transport-related proteins in children with kidney stones and suggests the need to check and attempt to treat lipid abnormalities in children with kidney stones, according to Dr. Kovacevic.

    “The results in this study support the significance of diet evaluation as part of the urolithiasis workup,” she said. “Special attention should be paid to the fat intake. The diet should be analyzed by a dietitian and should be modified accordingly. Additionally, these children may need the lipid profile in the blood tested and medically treated, if abnormal.”

    These interventions can be achieved by a multidisciplinary approach in the management of children with kidney stones. The urologist’s primary role would be to assess the need for surgical intervention and to perform it, if indicated, Dr. Kovacevic said.

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    The work is preliminary and based on only a small number of pediatric subjects. The next step, according to Dr. Kovacevic, is to validate the study’s findings in a larger sample.

    “The cause-effect relationship between these lipid metabolism/transport-related proteins and kidney stone should be investigated. Additionally, the impact of dietary change on the urinary excretion of lipoproteins should be studied,” she said.

    The results could have major diagnostic and treatment implications for pediatric kidney stone patients—many who have chronic issues with the stones, according to Dr. Kovacevic. While there are no incidence data about how many children get kidney stones, many specialists have reported seeing more children with kidney stones in recent years, according to the National Institutes of Health. And while they’re more common in adults, kidney stones do occur in infants, children, and teenagers from all ethnicities and races, according to NIH.

    More on Stone Disease:

    ‘Smart’ water bottle may help with stone prevention

    Top 10 stone disease articles of 2016

    Urolithiasis mortality rate high in lower income nations

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    Lisette Hilton
    Lisette Hilton, president of Words Come Alive, has written about health care, the science and business of medicine, fitness and wellness ...


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