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    Kidney Ca: Cytoreductive nephrectomy appears to be protective


    Not all chromatin modeling mutations are created equally. In 194 patients with clear cell renal cancer, the presence of only a PBRM1 mutation actually improved survival relative to those with neither mutation. In contrast, the presence of the BAP1 mutation with or without concomitant PBRM1 conferred dismal survival, dropping from a mean of 40 to 18 months.

    Continue to the next page for more take-home messages.

    Benjamin P. Saylor
    Saylor is content managing editor for Urology Times.


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