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    Hypogonadism raises cuff erosion risk in AUS patients

    Research needed on effect of testosterone supplementation prior to implantation

    Dallas—Hypogonadism in men undergoing artificial urinary sphincter (AUS) implantation significantly increases the risk of cuff erosion, according to the results of a study presented by urologists from UT Southwestern Medical Center, Dallas.

    Read: How cutting carbs may benefit men on hormonal therapy

    Interest in investigating an association between hypogonadism and AUS cuff erosion was prompted by a clinical observation that most patients presenting with a cuff erosion had a low serum testosterone level. The study, which included data for 52 patients who underwent AUS implantation between 2007 and 2014, showed in a multivariable regression analysis that hypogonadism was an independent predictor for cuff erosion, increasing the risk by 15-fold.

    In addition, findings from a Kaplan-Meier analysis indicated that cuff erosion was likely to occur within 8 years after AUS implantation in any man who was hypogonadal at the time of surgery.

    Matthias D. Hofer, MDDr. Hofer“The findings of this study provide useful information to include when counseling men before AUS implantation. Now, further study is needed to determine whether testosterone supplementation prior to surgery will mitigate the increased risk of cuff erosion after AUS implantation in hyogonadal men,” said Matthias D. Hofer, MD, who was a fellow in reconstructive urology, trauma, and prosthetics at UT Southwestern working with Allen Morey, MD, at the time of the study. Study results were presented at the AUA annual meeting in San Diego and subsequently published online in Urology (July 20, 2016).

    The study included men presenting consecutively to the clinic over a 2-month accrual period for a routine follow-up visit (n=33) or acutely with cuff erosion (n=19). Mean time to the follow-up visit post-AUS implantation was 2.8 years, and mean time to erosion was nearly 2 years with a range of approximately 1 month to 7 years.

    Next: T significantly lower in cuff erosion group

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