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    How do bladder Ca treatments compare in terms of survival?

    While they are different approaches to treating the same disease, there are no notable differences in overall survival, disease-specific survival, and progression-free survival between radical cystectomy and bladder-preserving combined modality treatment for muscle-invasive bladder cancer, according to a meta-analysis published in the International Journal of Radiation Oncology • Biology • Physics (2017; 97:1002-20).

    Higher rates of early major complications from cystectomy in this analysis of 12,380 patients provide compelling evidence that radiation therapy might be as good as surgery for many muscle-invasive bladder cancer patients, according to senior author Dharam Kaushik, MD. 

    Also see: Physical inactivity raises bladder cancer risk

    “Urologists are the primary point of contact for patients with bladder cancer. When it comes down to having a pragmatic and genuine discussion regarding various treatment options for muscle-invasive bladder cancer, more knowledge about the treatment modalities is in the best interest of the patient. Radical cystectomy remains the preferred option for the majority of patients, but this study opens the door to greater evaluation of radiation therapy as a beneficial alternative. The decision must be made on a case-by-case basis,” said Dr. Kaushik, of The University of Texas Health Science Center (now called UT Health San Antonio) and the UT Health Cancer Center, San Antonio.

    Dr. Kaushik and colleagues reviewed 19 randomized, controlled trials and prospective and retrospective studies comparing radical cystectomy with combined modality treatment, which is maximal transurethral resection of the bladder tumor and external-beam radiation therapy with concurrent chemotherapy. They evaluated survival rates and treatment-related complications by conducting meta-analyses of eight eligible studies, representing 9,554 subjects.

    Next: No significant differences in overall survival and disease-specific survival at 5 and 10 years

    Lisette Hilton
    Lisette Hilton, president of Words Come Alive, has written about health care, the science and business of medicine, fitness and wellness ...

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