• linkedin
  • Increase Font
  • Sharebar

    Genetic testing for prostate Ca: What the experts say

    A recently released statement from the Philadelphia Prostate Cancer Consensus Conference 2017 addresses the need for comprehensive expert guidance on genetic testing for inherited prostate cancer.

    Published online ahead of print in the Journal of Clinical Oncology (Dec. 13, 2017), the paper provides an evidence-based, consensus-driven framework on the role of genetic testing for determining prostate cancer risk, screening, and management.

    “Over the last few years, knowledge has increased regarding genes responsible for inherited prostate cancer as well as the capability to do genetic testing, but there is limited guidance on genetic evaluation for men with prostate cancer,” said Veda N. Giri, MD, of Sidney Kimmel Cancer Center (SKCC), Thomas Jefferson University, Philadelphia.

    “This consensus conference generated a centralized guideline statement on genetic testing and counseling that is specific for men with prostate cancer. It represents an important first step in pulling together the evidence and expertise in this field, and we expect that it will be expanded and modified over time based on evolving research.”

    “The field of genetic testing for prostate cancer is moving ahead rapidly,” said Leonard G. Gomella, MD, of Thomas Jefferson University.

    “Urologists are usually the first providers to diagnose and counsel men with prostate cancer. Understanding what is known and what are the limitations of prostate cancer genetic testing is essential.”

    The conference was hosted by the SKCC. Karen E. Knudsen, PhD, director, SKCC, served as co-chair of the panel along with Dr. Giri and Dr. Gomella. The panel included 68 additional members representing an international group of experts in medical oncology, radiation oncology, urology, clinical cancer genetics, genetic counseling, population science, research, bioethics, advocacy, and health policy.

    There was strong consensus that men with prostate cancer should undergo genetic counseling and genetic testing if they are from families meeting established testing or syndromic criteria for hereditary breast and ovarian cancer (HBOC), hereditary prostate cancer, or Lynch syndrome or if they have two or more close blood relatives on the same side of the family with cancers fitting any of the above cancer syndromes. The recommended tests were for BRCA1/2 in men meeting criteria for HBOC, HOXB13 in men meeting criteria for hereditary prostate cancer, and DNA mismatch repair genes for men meeting criteria for Lynch syndrome.

    Next: An important take-home


    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available