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    Embolization for BPH shows long-term safety, efficacy

    Statistically significant improvements seen in PVR, peak urinary flow rate

    Findings of a retrospective study including 1,000 men with follow-up ranging to 8 years demonstrate the long-term safety and efficacy of prostatic artery embolization (PAE) for relieving lower urinary tract symptoms secondary to BPH, researchers reported at the Society of Interventional Radiology annual scientific meeting in Washington.

    “This first-of-its-kind study provides clear evidence of the safety and long-term effectiveness of PAE as a treatment of BPH. We believe that these data, considered together with the benefits of PAE, support its presentation as a minimally invasive option to men seeking intervention for relief of BPH-related symptoms,” said lead author João M. Pisco, MD, PhD, professor of radiology at the New University of Lisbon, Lisbon, Portugal.

    Also see: 5-ARIs linked to increased risk of self-harm, depression

    Dr. Pisco noted that PAE can be performed under local anesthesia as an outpatient procedure. Compared with some other procedures, he said PAE is less invasive and is associated with a shorter recovery and minimal risk of sexual dysfunction.

    “Time and time again, I have seen patients who are not able to tolerate the side effects of medications for BPH but who do not want traditional surgery because of its risks, recovery period, and sexual side effects. Many of these men are grateful to learn about PAE as an alternative,” said Dr. Pisco.

    “Nevertheless, PAE may not be appropriate for all patients. In particular, it may not be technically feasible in men with advanced arterial atherosclerosis that may be related to smoking or diabetes. Patients should speak with an interventional radiologist or other members of their care team to discuss whether PAE is a viable option and learn about its risks and benefits.”

    The retrospective analysis included men who underwent PAE between March 2007 and March 2016. In a small percentage of patients (<2%), PAE could not be performed because of anatomic issues; ie, tortuosity and atherosclerotic changes of the iliac and prostatic arteries or a very angled origin of the prostatic artery.

    Follow-up evaluations were scheduled at 1, 3, and 6 months after PAE and then at 6-month intervals until 3 years. Thereafter, men returned for annual examinations. All men were available for early follow-up analyses (through 6 months), 807 men completed medium-term follow-up (6 months to 3 years), and data were available from 406 men who had long-term follow-up (>3 years).

    Next: All parameters show significant improvement

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    • Anonymous
      I think we need a bit more data yet; one centre studies are going to be biased; this short report does not mention flow rates, residual urines etc. What number of men went on to have further treatment?