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NSAID, ED link found by study


Men who take nonsteroidal anti-inflammatory drugs three times per day for more than 3 months are 2.4 times more likely to have erectile dysfunction than men who do not take the drugs regularly, say researchers from several California locations of Kaiser Permanente.

The observational study used electronic health records to examine NSAID use and ED in an ethnically diverse population of 80,966 men aged 45 to 69 years throughout California. After controlling for age, race, ethnicity, smoking status, and certain health conditions, the researchers found that ED was 1.4 times more likely among regular NSAID users compared with men who did not take the drugs regularly. This association was consistent across all age groups.

"This study is a great example of how we work to understand the safety and effectiveness of what we recommend for our patients," said senior author Steven J. Jacobsen, MD, PhD, of Kaiser Permanente Southern California, Pasadena. "We went into this study thinking we would find the opposite effect: that NSAIDs would have a protective effect because they protect against heart disease, which is also linked to ED. The next step is to dive a bit deeper to understand the underlying physiology of what might be happening with these drugs."

Results from the study were published online in the Journal of Urology (Feb. 18, 2011).

The 5-alpha-reductase inhibitor dutasteride (Avodart) appears to slow the growth of early-stage prostate cancer among men undergoing active surveillance, according to data presented at the Genitourinary Cancers Symposium in Orlando, FL.

The FDA recently approved the remainder of Dendreon Corp.?s manufacturing facility, which will add 36 workstations for the manufacture of sipuleucel-T (Provenge), the company?s advanced prostate cancer immunotherapy.

Researchers at the University of Michigan Comprehensive Cancer Center, Ann Arbor, have identified a potential target to treat an aggressive type of prostate cancer.

Researchers at the Institute for Regenerative Medicine have used patients? own cells to build tailor-made urethras and successfully replace damaged tissue.


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