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    Chemo improves QoL in men with non-metastatic, metastatic PCa


    “We already knew that docetaxel prolongs survival for men with metastatic prostate cancer,” Dr. James said, “but this improvement in quality of life and reduction in subsequent treatment, and therefore costs, in non-metastatic disease is somewhat surprising and may cause clinicians to rethink how and when they use docetaxel to treat prostate cancer.”

    Urologist Ganesh Raj, MD, of UT Southwestern Medical Center, Dallas, said this study has the potential to change the clinical paradigm.

    “While the addition of six courses of chemotherapy can be associated with significant toxicity, the authors suggest that for this cohort of patients, the benefits of combining docetaxel with standard hormonal therapy and local therapy outweigh the risk, both in terms of overall survival and quality of life. The findings are provocative and may herald the use of multimodal therapy in non-metastatic prostate cancer,” Dr. Raj told Urology Times.

    Read - PSA screening: What do you tell primary care docs?

    Mark Garzotto, MD, of Oregon Health & Science University and Portland VA Medical Center, Portland, agrees and said this study is particularly impressive given that there can be significant toxicity from chemotherapy treatment itself. However, he said men with non-metastatic prostate cancer are a very diverse group with a wide-spectrum of clinical outcomes.

    “Characterizing precisely which patient populations will derive these benefits is of critical importance going forward,” Dr. Garzotto told Urology Times. “Additional questions that need to be answered include whether novel hormone agents can achieve similar or better outcomes as shown in STAMPEDE.”

    Dr. James has received honoraria from and serves as a consultant/adviser to Sanofi/Aventis and several other pharmaceutical companies. He also serves on the speakers’ bureau for several pharmaceutical companies. His institution has also received research funding from Sanofi/Aventis and several other pharmaceutical companies. For full disclosures, click here.

    More from Urology Times:

    Prostate Ca test linked to reduction in biopsies

    Biennial vs. annual prostate biopsies: What the data show

    Genetic testing for prostate Ca: What the experts say

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