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    Can Gleason 7 cancer be low-risk disease?

    In men with three or fewer positive cores, recurrence rate similar in Gleason ≤6, 7

    Durham, NC—Findings from a retrospective study lend support to the idea that even in men with a Gleason 7 (3+4) biopsy score, prostate cancer may sometimes act like low-risk disease. 

    Related: New PCa test outperforms PSA in men with Gleason ≥7 disease

    The research, presented at the AUA annual meeting in New Orleans, used the Shared Equal Access Regional Cancer Hospital (SEARCH) database to identify men who underwent radical prostatectomy between 2001 and 2013 and had a PSA ≤10.0 ng/mL, stage cT1c/T2a prostate cancer, more than eight cores taken on biopsy, and a biopsy Gleason score ≤7 (3+4 only for a score of 7). In analyses restricted to men with three or fewer positive cores, comparisons between groups with a biopsy Gleason score ≤6 versus a Gleason biopsy score of 7 found no significant differences in the biochemical recurrence rate or in certain adverse pathologic outcomes, reported first author Kathleen McGinley, DO.

    Also see: How much does treating low-risk PCa really cost?

    “These findings add to a growing body of studies addressing the question of whether certain men with intermediate-risk prostate cancer could be reasonable candidates for active surveillance,” said Dr. McGinley, a Society of Urologic Oncology fellow in the division of urology, Duke University Medical Center, Durham, NC.

    Next: "We must be cautious about trying to extrapolate our findings"


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