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    C-11 choline PET, pMRI identify recurrence patterns

    Higher than anticipated frequency of metastatic prostate Ca recurrence observed

    San Francisco—C-11 choline positron emission tomography (PET) and multiparametric pelvic magnetic resonance imaging (pMRI) can be used successfully to identify recurrence patterns in patients with biochemical recurrence after radical prostatectomy. 

    Related: PCa agent detects 97% of lesions when paired with PET

    Use of such imaging shows a low rate of local-only recurrence at a median PSA level of 2.3 ng/mL but a higher than anticipated frequency of metastatic recurrence, reported researchers from Mayo Clinic, Rochester, MN.

    At the Genitourinary Cancers Symposium in San Francisco, they presented data from a cohort of 260 men evaluated with choline PET and pMRI for suspected prostate cancer relapse after prostatectomy.

    Despite the high rate of distant recurrence in the cohort studied, two-thirds of patients had disease limited to the pelvis, making them potential candidates for local therapies, including salvage radiation, said Ilya Sobol, MD, a Mayo Clinic urology resident working with Eugene D. Kwon, MD, and colleagues.

    Also see - Surveillance: Reclassification risk drops after 2 years

    C-11 choline PET uses choline C-11 as a tracer, which is taken up rapidly by prostate cancer cells prior to PET imaging, which detects the location of tracer concentrations. C-11 choline PET has been used in Europe for more than 10 years to detect recurrent prostate cancer, and now has been surpassed by even more accurate imaging techniques such as (68)Ga-labeled PMSA scan, which is not currently approved by the FDA.

    Next: “It is able to detect recurrent prostate cancer, particularly in soft tissue and in bone, much better than anything else we’ve had before"

    Wayne Kuznar
    Wayne Kuznar is a contributor to Urology Times.


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