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    Bx-related complications influence decision-making

    PCa patients experiencing a complication more likely to seek active treatment

    Boston—Men who experience a prostate biopsy-related complication are more likely to seek active treatment for clinically localized prostate cancer than those who do not experience a complication, according to findings from a review of the Surveillance, Epidemiology, and End Results Medicare linked database.

    The odds of choosing active surveillance was reduced by 17% among men who had a complication after transrectal prostate biopsy compared with the reference group (no complication after biopsy), said first author Melanie Adamsky, MD, at the AUA annual meeting in Boston.

    Data suggest that experiencing a biopsy-related complication does not increase the risk of complications with future biopsies, nor do men with biopsy-associated complications have worse oncologic outcomes, said Dr. Adamsky, urology resident at the University of Chicago.

    Read: AUA issues recommendations on surveillance, opioids

    “Our findings underscore the importance of counseling patients about the relative safety of active surveillance, even among men who’ve experienced complications after biopsy,” added Dr. Adamsky, who worked on the study with Brian T. Helfand, MD, PhD, and co-authors.

    Her group looked at patients diagnosed with low-risk or low-volume, intermediate-risk prostate cancer and whether experiencing a complication upon a diagnostic prostate biopsy influenced their treatment decision. They identified 8,932 men with Gleason 6, clinical stage I or Gleason 3+4=7, clinical stage I prostate cancer from the SEER-Medicare linked database between 2009 and 2011. The men were assessed for adverse events or complications coded within 30 days of biopsy, including infectious complications (kidney infection, urinary tract infection, prostatitis, cystitis, sepsis/bacteremia, endocarditis, hypertension, and postoperative infection) and noninfectious complications (gastrointestinal hemorrhage, hematuria, acute post-hemorrhagic anemia, and urinary symptoms or retention).

    About 2% of men experienced infectious complications and 15% had noninfectious complications after their biopsy, said Dr. Adamsky.

    The outcome of interest was treatment decision. Active surveillance was defined as absence of treatment within 1 year of diagnosis and one or more biopsies within 2 years of diagnosis. Active treatment was defined as prostatectomy, radiation, cryotherapy, or androgen deprivation therapy as primary therapy.

    Next: Complication type affects decision

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