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    Blue light cystoscopy improves bladder Ca detection

    Detection of carcinoma in situ, papillary tumors improved in phase III study


    Additional tumors found with blue light

    A secondary outcome analysis of the OR data showed blue light rigid cystoscopy with HAL detected additional tumors compared with white light cystoscopy in 30 patients (46.2%). Of the 26 patients with confirmed CIS, nine (34.6%) had their lesion detected only with blue light cystoscopy (p<.0001).

    The incidence of adverse events considered causally related to blue light and/or HAL was low both in the surveillance examination (2.0%) and in the OR examination (2.9%).

    “There were no indications of increased adverse events with repeated blue light cystoscopy,” Dr. Daneshmand said.

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    Surgeons were also asked how findings of the surveillance cystoscopy under blue light might have influenced their management of a patient in clinical practice. They were given four response options, and the results showed that one-third of the time, the findings would have caused surgeons to change their management.

    Patient-reported outcome data were collected as well. For both the blue light surveillance exam and OR exam, about 90% of patients felt the procedure was worthwhile, said they would undergo it again, and would recommend it to others.

    Dr. Daneshmand is a paid consultant to Photocure. Several of his co-authors are scientific study/trial participants for Photocure and/or have a financial or other relationship with several pharmaceutical companies.

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