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    Bladder Ca linked to risk of second primary cancer

    Among survivors of the most common types of cancer, bladder cancer survivors had the highest risk for developing a second primary cancer, with lung cancer being the leading type, according to a recent study.

    Second malignancies are not only very common among cancer survivors but also highly lethal, researchers found. 

    Related: Bladder Ca guide provides risk-stratified framework

    “In 2012, there were 14 million cancer survivors in the United States, and that number is expected to reach close to 20 million by 2024. Our study underscores the point that there is a large cohort of patients who will develop a second primary cancer and die from it,” lead author Nicholas Donin, MD, told Urology Times.

    “In addition, it is one of the first studies to formally show a connection between lung cancer and bladder cancer. Although the finding may not be surprising considering that a smoking history increases risk for both types of cancers, it is important because it should alert urologists to how common and dangerous lung cancer is as a second primary malignancy among bladder cancer survivors and raise awareness that there is Level 1 evidence to show that screening for lung cancer saves lives,” added Dr. Donin, of the University of California, Los Angeles, working with Karim Chamie, MD, and co-authors.

    Also see: What anti-PD-L1 immunotherapy approval means for urology

    For the study, which was published online in Cancer (July 5, 2016), the authors used the Surveillance, Epidemiology, and End Results database to identify 2,116,163 adults who were diagnosed between 1992 and 2008 with a primary malignancy from the 10 most common cancer sites (prostate, breast, lung, colon, rectum, bladder, uterus, kidney, melanoma, and non-Hodgkin lymphoma). During a mean follow-up of 7.1 years, 170,865 patients—1 in 12—developed a second primary malignancy, defined as a cancer with a different pathologic diagnosis diagnosed >1 year after the first malignancy. Lung cancer was the most common type of second primary cancer, accounting for 18% of those malignancies.

    Next: Among bladder Ca survivors, 19% developed a second primary malignancy within 10 years of their primary Ca diagnosis

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