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    Antiandrogen’s role may extend to non-metastatic CRPC

    Top-line results from the phase III PROSPER trial support a potential role for enzalutamide (XTANDI) as treatment for non-metastatic castration-resistant prostate cancer (CRPC).

    The efficacy analysis showed that the study met its primary endpoint by demonstrating that the combination of enzalutamide plus androgen deprivation therapy (ADT) was associated with a statistically significant improvement in metastasis-free survival (radiographically detected metastasis). Thus, enzalutamide becomes the first androgen receptor inhibitor to show in a randomized, controlled trial improvement in metastasis-free survival in men with non-metastatic CRPC.

    Read: Immune content linked to aggressive PCa outcomes

    “When the full PROSPER results are available, they will hopefully confirm metastasis-free survival is significantly improved for men who received enzalutamide plus ADT compared to men receiving ADT alone. While there are currently no FDA-approved treatments for men who have non-metastatic CRPC, we may have an agent in the future that will allow us to treat these men earlier, rather than waiting for them to develop confirmed radiographic metastatic disease,” said PROSPER investigator and steering committee member Neal Shore, MD, of Carolina Urologic Research Center, Myrtle Beach, SC.

    “A delay in the development of metastatic cancer is important in the journey of a prostate cancer patient. To have the option to prescribe a once-a-day therapy that can be taken with or without food, and without stringent laboratory requirements, would provide flexibility for the provider and the patient.”

    Next: Safety profile was consistent with that reported in previous clinical trials

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