• linkedin
  • Increase Font
  • Sharebar

    5-ARI use does not raise erectile dysfunction risk

    ED risk increases with longer duration of BPH, researchers report


    Results null regardless of timing of use

    In the cohort study, the odds ratio for ED was 0.94 (95% CI: 0.85-1.03) with use of a 5-ARI only and 0.92 (95% CI: 0.80-1.06) for use of both a 5-ARI and an alpha-blocker compared with an alpha-blocker only. A nested case-control analysis in which each man with ED was matched with at least four men without ED revealed that the results remained null regardless of the number of prescriptions or the timing of use.

    In an analysis stratified by duration of BPH, the risk of ED increased with longer duration of BPH, regardless of 5-ARI exposure. For instance, with BPH duration of 6 months to 1 year, the odds of ED were 1.15 with an alpha-blocker only, 0.96 with a 5-ARI only, and 0.96 when using both. With BPH duration of 5 years or longer, these odds increased to 2.80 with an alpha-blocker only, 1.54 with a 5-ARI only, and 2.55 with use of both.

    Have you read: 5-ARI may have adverse metabolic effects

    The real-world data examined are an advantage over previous studies exploring the relationship between 5-ARI use and ED, said Dr. Nickel.

    “This is a real-life clinical situation of ED presenting to physicians so it’s clinically meaningful, whereas in the other studies it’s not… patients didn’t care and didn’t want to be treated,” he said.

    More from Urology Times:

    Side effects of modern PCa treatments compared

    Life vs. quality of life: A delicate balance

    New diagnostic tests for male infertility

    Subscribe to Urology Times to get monthly news from the leading news source for urologists.


    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available


    View Results