• linkedin
  • Increase Font
  • Sharebar

    Best of AUA 2014: Bladder Cancer

    Click here for more Best of AUA 2014 coverage

    Presented by Wassim Kassouf, MD, CM,
    McGill University, Montreal

    Wassim Kassouf, MD, CM

    • Both men and women experience significant delays between presentation with microhematuria and bladder cancer diagnosis, but longer delays are seen in women, which may partly explain the gender-based discrepancies published in recent years.

    • Risk of urinary tract malignancy in over 7,000 patients with asymptomatic microhematuria was 2.4%—useful information for counseling patients regarding a hematuria workup.

    • Screening men aged 60 to 80 years with a smoking history of more than 30 pack-years yielded a bladder cancer incidence rate of 2/1,000 person years.

    • In nonmuscle-invasive disease, a study comparing Hexvix transurethral resection of bladder tumor (TURBT) plus mitomycin with white-light TURBT plus mitomycin found no impact on recurrence nor progression in patients undergoing Hexvix TURBT plus mitomycin at 3 years.

    • The combination of bacillus Calmette-Guérin (BCG) plus interferon showed significantly lower recurrence rates and significantly less toxicity compared to patients treated with BCG in a randomized, prospective trial.

    • Sequential BCG/electromotive mitomycin for high-risk disease showed an 84% complete response rate at 1 year, but 29% of patients did not tolerate the nine-dose full-induction course.

    • Upper tract and/or urethral cancer was detected during long-term follow-up in more than 50% of patients with high-risk nonmuscle-invasive disease failing at least two courses of BCG. In the stratification of T1 disease, both the a/b classification and the extensive versus microinvasive stratification were validated to significantly predict progression.

    • In invasive bladder cancer, sarcopenia is associated with increased complications, increased mortality, and decreased cancer-specific survival after radical cystectomy, and is prognostic in patients with metastatic disease.

    • Neutrophil-to-lymphocyte ratio was an independent prognostic factor in patients treated with radical cystectomies in multiple abstracts.

    Continue to the next page for more.

    0 Comments

    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available

    Poll

    View Results