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Hot Topics in Prostate Cancer

Immune content linked to aggressive PCa outcomesThe level of immune response in prostate cancer may predict a patient’s response to radiation therapy, risk of disease recurrence, and survival outcomes, according to results of a recent analysis of prostate tumors.
Antiandrogen’s role may extend to non-metastatic CRPCTop-line results from a large phase III trial support a potential role for enzalutamide (XTANDI) as treatment for non-metastatic castration-resistant prostate cancer.
Prostate Ca study reveals more evidence of racial disparityResults of a study examining receipt of definitive therapy for intermediate/high-risk localized prostate cancer provide further evidence of racial disparity in prostate cancer favoring Caucasian men over African-American men.
Quality initiative could reduce unnecessary PCa bone scansOne gentle “nudge” may be all it takes to start reducing the number of unnecessary bone scans ordered for asymptomatic men with low-risk prostate cancer, results of a recent quality improvement intervention suggest.
Prostate MRI has value, but results are not ‘gospel’Magnetic resonance imaging (MRI) of the prostate may be used in many clinical scenarios, including primary screening, active surveillance, and in patients with a previous negative biopsy and rising PSA. In this interview, Scott Eggener, MD, explains whether MRI is warranted in each of these situations and the benefits and challenges this technology presents.
Metformin may improve advanced prostate Ca outcomesMetformin may act synergistically with androgen deprivation therapy to improve outcomes for men with advanced prostate cancer, according to findings of an observational study presented at the AUA annual meeting in Boston.
Research reveals possible predictor of PCa germline mutationThe study of men with prostate cancer also found that the majority of the men with a germline cancer predisposition gene mutation did not meet existing criteria for clinical genetic testing.
How do height, adiposity affect prostate Ca risk?Taller men and those with greater adiposity are at increased risk of having high-grade prostate cancer and of dying from their malignancy, according to recently published research.
Factors in prostate Ca decision-making vary by racePatients newly diagnosed with prostate cancer show race-related differences in what men perceive as important factors in their treatment decision-making process.
Prostate Cancer: Studies suggest strategies for marker, mpMRI useFindings from the ProtecT trial, the European Randomized study of Screening for Prostate Cancer, and PIVOT were among the other noteworthy studies in prostate cancer presented at the AUA annual meeting.