Cheryl Guttman Krader
Sirolimus shows promise for posterior segment non-infectious uveitis
Intravitreal sirolimus 400 mcg (Ospiria, Santen) demonstrated positive results in pivotal trials investigating it as a treatment for non-infectious uveitis of the posterior segment. A New Drug Application is under FDA review.
Systemic safety of anti-VEGF treatment for ROP mandates further study
Systemic safety of anti-VEGF treatment for ROP mandates further study
Accumulating evidence is cause for concern and underscoring the need for more research evaluating the safety of anti-VEGF injections for ROP, according to Robert L. Avery, MD.
Prostate Ca immunotherapy induces T-cell response
A study aimed at further elucidating the mechanism of action of sipuleucel-T (Provenge) in advanced prostate cancer provides fairly convincing evidence that the immunotherapy agent induces T-cell responses in humans, says Charles G. Drake, MD, PhD.
Factors in prostate Ca decision-making vary by race
Patients newly diagnosed with prostate cancer show race-related differences in what men perceive as important factors in their treatment decision-making process.
BMI predicts post-RP metastasis, PCa mortality
Findings from a recent study also suggest that obesity may be a factor to consider for men with prostate cancer deciding between active surveillance and definitive treatment.
Pre-RP MRI does not affect surgical outcomes
Results of a retrospective case-cohort study show no significant differences in surgical outcomes among men who did and did not have preoperative magnetic resonance imaging of the prostate prior to radical prostatectomy for prostate cancer.
AUA issues recommendations on surveillance, opioids
Continuing its participation in the Choosing Wisely campaign, the AUA has added five new recommendations about tests and treatments that physicians and patients should question.
New pathways to cancer therapy
A novel oral formulation of itraconazole (SUBA-Itraconazole, HedgePath Pharmaceuticals) is providing dramatic benefit for patients with basal cell carcinoma nevus syndrome (BCCNS, also known as Gorlin syndrome) and with a favorable safety profile, according to a recent interim analysis of data collected in a phase IIb study.
Sulcus refractive IOLs solid option for presbyopia, other refractive errors
Implantation of a sulcus-supported, pseudophakic supplementary intraocular lens (IOL) can be a safe and effective method for improving vision in eyes with residual refractive error after cataract extraction, refractive lens exchange, or keratoplasty, said Thomas Kohnen, MD, PhD. It also can be used to provide reversible presbyopia correction.
Metastatic PCa: Studies point to new standard of care
“Abiraterone should change the treatment paradigm for patients with newly diagnosed metastatic prostate cancer and largely displaces chemotherapy from the current paradigm,” said Sumanta Kumar Pal, MD.

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